Publications

D. Bourassa, S.C. Gleber, S. Vogt, C.H. Shin, C.J. Fahrni, "MicroXRF tomographic visualization of zinc and iron in the zebrafish embryo at the onset of the hatching period", Metallomics 2016, 8, doi:10.1039/C6MT00073H. [pubmed] [link]

M.T. Morgan, A.M. McCallum, C.J. Fahrni, "Rational design of a water-soluble, lipid-compatible fluorescent probe for Cu (I) with sub-part-per-trillion sensitivity", Chem. Sci. 2016, 7, 1468-1473. [pubmed] [link]

Y.C. Chen, A.E. Jablonski, I. Issaeva, D. Bourassa, J.C. Hsiang, C.J. Fahrni, R.M. Dickson, "Optically modulated photoswitchable fluorescent proteins yield improved biological imaging sensitivity", J. Am. Chem. Soc. 2015, 40, 12764-12767. [pubmed] [link]

F. Friscourt, C.J. Fahrni, G.J. Boons, "Fluorogenic strain-promoted alkyne-diazo cycloadditions", Chem. Eur. J. 2015, 21, 13996-14001. [pubmed] [link]

M.T. Morgan, S. Sumalekshmy, M. Sarwar, H. Beck, S. Crooke, C.J. Fahrni, "Probing ternary complex equilibria of crown ether ligands by time-resolved fluorescence spectroscopy", J. Phys. Chem. B 2014, 118, 14196-14202. [pubmed] [link]

D. Bourassa, S.-C. Gleber, S. Vogt, H. Yi, F. Will, H. Richter, C.H. Shin, C.J. Fahrni, "3D Imaging of Transition Metals in the Zebrafish Embryo by X-ray Fluorescence Microtomography”, Metallomics 2014, 6, 1648-1655. [pubmed] [link]

P. Bagchi, M.T. Morgan, J. Bacsa, C.J. Fahrni, “Robust affinity standards for Cu(I) biochemistry”, J. Am. Chem. Soc. 2013, 135, 18549-59. [pubmed] [link]

McRae, R.; Lai, B.; Fahrni, C. J., "Subcellular redistribution and mitotic inheritance of transition metals in proliferating mouse fibroblast cells.", Metallomics 2013, 5, 52-61. [pubmed] [link]

Fahrni, C. J., "Synthetic fluorescent probes for monovalent copper.", Curr. Opin. Chem. Biol. 2013, 17, 656-62 [pubmed] [link]

Morgan, M. T.; Bagchi, P.; Fahrni, C. J., "High-contrast fluorescence sensing of aqueous Cu(I) with triarylpyrazoline probes: dissecting the roles of ligand donor strength and excited state proton transfer.", Dalton Trans. 2013, 42, 3240-3248. [pubmed] [link]

Nekongo, E. E.; Bagchi, P.; Fahrni, C. J.; Popik, V. V., "9-Aryl-9-xanthenols: a convenient platform for the design of fluorimetric and colorimetric pH indicators.", Org. Biomol. Chem. 2012, 10, 9214-9218. [pubmed] [link]

Jablonski, A.; Hsiang, J. C.; Bagchi, P.; Hull, N.; Richards, C. I.; Fahrni, C. J.; Dickson, R. M., "Signal discrimination between fluorescent proteins in live cells by long-wavelength optical modulation", J. Phys. Chem. Lett. 2012, 3, 3585-3591. [pubmed] [link]

Friscourt, F.; Fahrni, C. J.; Boons, G.-J., "A fluorogenic probe for the catalyst-free detection of azide-tagged molecules.", J. Am. Chem. Soc. 2012, 134, 18809-18815. [pubmed] [link]

Sumalekshmy, S.; Fahrni, C. J., "Metal-ion-responsive fluorescent probes for two-photon excitation microscopy", Chem. Mat. 2011, 823-830. [link]

Morgan, M. T.; Bagchi, P.; Fahrni, C. J., "Designed to dissolve: Suppression of colloidal aggregation of Cu(I)-selective fluorescent probes in aqueous buffer and in-gel detection of a metallochaperone.", J. Am. Chem. Soc. 2011, 133, 15906-15909. [pubmed] [link]

Chaudhry, A. F.; Mandal, S.; Hardcastle, K. I.; Fahrni, C. J., "High-contrast Cu(I)-selective fluorescent probes based on synergistic electronic and conformational switching", Chem. Sci. 2011, 2, 1016-1024. [pubmed] [link]

Verma, M.; Chaudhry, A. F.; Morgan, M. T.; Fahrni, C. J., "Electronically tuned 1,3,5-triarylpyrazolines as Cu(I)-selective fluorescent probes", Org. Biomol. Chem. 2010, 8, 363-370. [pubmed] [link]

McRae, R.; Lai, B.; Fahrni, C. J., "Copper redistribution in Atox1-deficient mouse fibroblast cells", J. Biol. Inorg. Chem. 2010, 15, 99-105. [pubmed] [link]

Chaudhry, A. F.; Verma, M.; Morgan, M. T.; Henary, M. M.; Siegel, N.; Hales, J. M.; Perry, J. W.; Fahrni, C. J., "Kinetically Controlled Photoinduced Electron Transfer Switching in Cu(I)-Responsive Fluorescent Probes", J. Am. Chem. Soc. 2010, 132, 737-747. [pubmed] [link]

Verma, M.; Chaudhry, A. F.; Fahrni, C. J., "Predicting the photoinduced electron transfer thermodynamics in polyfluorinated 1,3,5-triarylpyrazolines based on multiple linear free energy relationships", Org. Biomol. Chem. 2009, 7, 1536-1546. [pubmed] [link]

McRae, R.; Bagchi, P.; Sumalekshmy, S.; Fahrni, C. J., "In situ imaging of metals in cells and tissues", Chem. Rev. 2009, 109, 4780-4827. [pubmed] [link]

Fahrni, C. J., "Fluorescent probes and labels for cellular imaging", Chimia 2009, 63, 714-720. [link]

Solntsev, K. M.; McGrier, P. L.; Fahrni, C. J.; Tolbert, L. M.; Bunz, U. H. F., "Anomalous photophysics of bis(hydroxystyryl)benzenes: A twist on the para/meta dichotomy", Org. Lett. 2008, 10, 2429-2432. [pubmed] [link]

McRae, R. L.; Phillips, R. L.; Kim, I. B.; Bunz, U. H. F.; Fahrni, C. J., "Molecular recognition based on low-affinity polyvalent interactions: Selective binding of a carboxylated polymer to fibronectin fibrils of live fibroblast cells", J. Am. Chem. Soc. 2008, 130, 7851-7853. [pubmed] [link]

Cody, J.; Mandal, S.; Yang, L. C.; Fahrni, C. J., "Differential tuning of the electron transfer parameters in 1,3,5-triarylpyrazolines: A rational design approach for optimizing the contrast ratio of fluorescent probes", J. Am. Chem. Soc. 2008, 130, 13023-13032. [pubmed] [link]

Wu, Y. G.; Lawson, P. V.; Henary, M. M.; Schmidt, K.; Bredas, J. L.; Fahrni, C. J., "Excited state intramolecular proton transfer in 2-(2 '-arylsulfonamidophenyl)benzimidazole derivatives: Insights into the origin of donor substituent-induced emission energy shifts", J. Phys. Chem. A 2007, 111, 4584-4595. [pubmed] [link]

Sumalekshmy, S.; Henary, M. M.; Siegel, N.; Lawson, P. V.; Wu, Y.; Schmidt, K.; Bredas, J. L.; Perry, J. W.; Fahrni, C. J., "Design of emission ratiometric metal-ion sensors with enhanced two-photon cross section and brightness", J. Am. Chem. Soc. 2007, 129, 11888-11889. [pubmed] [link]

Henary, M. M.; Wu, Y. G.; Cody, J.; Sumalekshmy, S.; Li, J.; Mandal, S.; Fahrni, C. J., "Excited-state intramolecular proton transfer in 2-(2 '-arylsulfonamidophenyl)benzimidazole derivatives: The effect of donor and acceptor substituents", J. Org. Chem. 2007, 72, 4784-4797. [pubmed] [link]

Fahrni, C. J., "Biological applications of X-ray fluorescence microscopy: exploring the subcellular topography and speciation of transition metals", Curr. Opin. Chem. Biol. 2007, 11, 121-127. [pubmed] [link]

McRae, R.; Lai, B.; Vogt, S.; Fahrni, C. J., "Correlative microXRF and optical immunofluorescence microscopy of adherent cells labeled with ultrasmall gold particles", J. Struct. Biol. 2006, 155, 22-29. [pubmed] [link]

Yang, L.; McRae, R.; Henary, M. M.; Patel, R.; Lai, B.; Vogt, S.; Fahrni, C. J., "Imaging of the intracellular topography of copper with a fluorescent sensor and by synchrotron x-ray fluorescence microscopy.", Proc. Natl. Acad. Sci. USA 2005, 102, 11179-11184. [pubmed] [link]

Zhou, Z.; Fahrni, C. J., "A fluorogenic probe for the copper(I)-catalyzed azide-alkyne ligation reaction: Modulation of the fluorescence emission via (3)(n,pi*)-(1)(pi,pi*) inversion", J. Am. Chem. Soc. 2004, 126, 8862-8863. [pubmed] [link]

Samia, A. C. S.; Cody, J.; Fahrni, C. J.; Burda, C., "The effect of ligand constraints on the metal-to-ligand charge-tranfer relaxation dynamics of copper(I)-phenanthroline complexes: A comparative study by femtosecond time-resolved spectroscopy", J. Phys. Chem. B 2004, 108, 563-569. [link]

Henary, M. M.; Wu, Y. G.; Fahrni, C. J., "Zinc(II)-selective ratiometric fluorescent sensors based on inhibition of excited-state intramolecular proton transfer", Chem. Eur. J. 2004, 10, 3015-3025. [pubmed] [link]

Cody, J.; Fahrni, C. J., "Fluorescence sensing based on cation-induced conformational switching: copper-selective modulation of the photoinduced intramolecular charge transfer of a donor-acceptor biphenyl fluorophore", Tetrahedron 2004, 60, 11099-11107. [link]

Fahrni, C. J.; Yang, L. C.; VanDerveer, D. G., "Tuning the photoinduced electron-transfer thermodynamics in 1,3,5-triaryl-2-pyrazoline fluorophores: X-ray structures, photophysical characterization, computational analysis, and in vivo evaluation", J. Am. Chem. Soc. 2003, 125, 3799-3812. [pubmed] [link]

Cody, J.; Dennisson, J.; Gilmore, J.; VanDerveer, D. G.; Henary, M. M.; Gabrielli, A.; Sherrill, C. D.; Zhang, Y. Y.; Pan, C. P.; Burda, C.; Fahrni, C. J., "X-ray structures, photophysical characterization, and computational analysis of geometrically constrained copper(I)-phenanthroline complexes", Inorg. Chem. 2003, 42, 4918-4929. [pubmed] [link]

Henary, M. M.; Fahrni, C. J., "Excited state intramolecular proton transfer and metal ion complexation of 2-(2'-hydroxyphenyl)benzazoles in aqueous solution", J. Phys. Chem. A 2002, 106, 5210-5220. [link]

Fahrni, C. J.; Henary, M. M.; VanDerveer, D. G., "Excited-state intramolecular proton transfer in 2-(2'-tosylaminophenyl)benzimidazole", J. Phys. Chem. A 2002, 106, 7655-7663. [link]

Nasir, M. S.; Fahrni, C. J.; Suhy, D. A.; Kolodsick, K. J.; Singer, C. P.; O'Halloran, T. V., "The chemical cell biology of zinc: structure and intracellular fluorescence of a zinc-quinolinesulfonamide complex", J. Biol. Inorg. Chem. 1999, 4, 775-783. [pubmed] [link]

Fahrni, C. J.; Simon, K. D.; Suhy, D. A.; Nasir, M. S.; Dwivedi, R.; O'Halloran, T. V., "Investigation of intracellular zinc storage and transport with zinc specific fluorescence probes", J. Inorg. Biochem. 1999, 74, 125-125.

Fahrni, C. J.; O'Halloran, T. V., "Aqueous coordination chemistry of quinoline-based fluorescence probes for the biological chemistry of zinc", J. Am. Chem. Soc. 1999, 121, 11448-11458. [link]

Fahrni, C. J.; Pfaltz, A.; Neuburger, M.; Zehnder, M., "Structure and properties of transition-metal complexes with chiral C-2-symmetric binucleating ligands", Helv. Chim. Acta 1998, 81, 507-524. [link]

Fahrni, C. J.; Pfaltz, A., "Synthesis of chiral C2-symmetric binucleating ligands", Helv. Chim. Acta 1998, 81, 491-506. [link]

Fahrni, C. J., "Allylic oxidation catalyzed by chiral dinuclear copper complexes", Tetrahedron 1998, 54, 5465-5470. [link]

Pufahl, R. A.; Singer, C. P.; Peariso, K. L.; Lin, S. J.; Schmidt, P. J.; Fahrni, C. J.; Culotta, V. C.; Penner-Hahn, J. E.; O'Halloran, T. V., "Metal ion chaperone function of the soluble Cu(I) receptor Atx1.", Science 1997, 278, 853-856. [pubmed] [link]