Center for Bio-Imaging Mass Spectrometry

The goal of the Bio Imaging Mass Spectrometry Center (BIMS) is to further the development of techniques, instrumentation and the fundamental understanding of mass spectrometry used to produce 2D and 3D images of biological samples. The Center also provides a venue to discus success as well as troubleshoot difficulties encountered while undertaking projects related to this research. 


Parry RM, Galhena AS, Gamage CM, Bennett RV, Wang MD, Fernandez FM. "OmniSpect: An Open MATLAB-Based Tool for Visualization and Analysis of Matrix-Assisted Laser Desorption/Ionization and Desorption Electrospray Ionization Mass Spectrometry Images". J Am Soc Mass Spectrom, 2013, 24(4): 646-9. PMCID:23440717.

Monge ME, Harris GA, Dwivedi P, Fernandez FM. "Mass spectrometry: recent advances in direct open air surface sampling/ionization". Chem Rev, 2013, 113(4): 2269-308. PMCID:23301684.

Kaddi CD, Parry RM, Wang MD. "Multivariate hypergeometric similarity measure". IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2013: In press.

Bennett RV, Cleaves HJ, Davis JM, Sokolov DA, Orlando TM, Bada JL, Fernandez FM. "Desorption Electrospray Ionization Imaging Mass Spectrometry as a Tool for Investigating Model Prebiotic Reactions on Mineral Surfaces". Anal Chem, 2013, 85(3): 1276-9. PMCID:WOS:000314676100005.

Kaddi CD, Parry RM, Wang MD. Multivariate hypergeometric similarity measure.  Proceedings of the ACM Conference on Bioinformatics, Computational Biology and Biomedicine; Orlando, Florida. 2382966: ACM; 2012. p. 234-41.

Andras TD, Alexander TS, Gahlena A, Parry RM, Fernandez FM, Kubanek J, Wang MD, Hay ME. "Seaweed allelopathy against coral: surface distribution of a seaweed secondary metabolite by imaging mass spectrometry". J Chem Ecol, 2012, 38(10): 1203-14. PMCID:23108534.

Sullards MC, Liu Y, Chen Y, Merrill AH, Jr. "Analysis of mammalian sphingolipids by liquid chromatography tandem mass spectrometry (LC-MS/MS) and tissue imaging mass spectrometry (TIMS)". Biochim Biophys Acta, 2011, 1811(11): 838-53. PMCID:21749933.

Murphy RC, Merrill AH, Jr. "Lipidomics and imaging mass spectrometry". Biochim Biophys Acta, 2011, 1811(11): 635-6. PMCID:21983393.

Merrill AH, Jr. "Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics". Chem Rev, 2011, 111(10): 6387-422. PMCID:21942574.

Symonds JM, Galhena AS, Fernandez FM, Orlando TM. "Microplasma Discharge Ionization Source for Ambient Mass Spectrometry". Anal Chem, 2010, 82(2): 621-7. PMCID:WOS:000273484200026.

Jung S, Chen Y, Sullards MC, Ragauskas AJ. "Direct analysis of cellulose in poplar stem by matrix-assisted laser desorption/ionization imaging mass spectrometry". Rapid Commun Mass Spectrom, 2010, 24(22): 3230-6. PMCID:20972996.

Galhena AS, Harris GA, Nyadong L, Murray KK, Fernandez FM. "Small molecule ambient mass spectrometry imaging by infrared laser ablation metastable-induced chemical ionization". Anal Chem, 2010, 82(6): 2178-81. PMCID:20155978.

Chen Y, Liu Y, Sullards MC, Merrill AH, Jr. "An introduction to sphingolipid metabolism and analysis by new technologies". Neuromolecular Med, 2010, 12(4): 306-19. PMCID:20680704.

Chen Y, Liu Y, Allegood J, Wang E, Cachon-Gonzalez B, Cox TM, Merrill AH, Jr., Sullards MC. "Imaging MALDI mass spectrometry of sphingolipids using an oscillating capillary nebulizer matrix application system". Methods Mol Biol, 2010, 656: 131-46. PMCID:20680588.

 Parry RM, Galhena AS, Fernandez FM, Wang MD. "Deblurring Molecular Images Using Desorption Electrospray Ionization Mass Spectrometry". 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols 1-20, 2009: 6731-4. PMCID:WOS:000280543605142.

Nyadong L, Hohenstein EG, Galhena A, Lane AL, Kubanek J, Sherrill CD, Fernandez FM. "Reactive desorption electrospray ionization mass spectrometry (DESI-MS) of natural products of a marine alga". Anal Bioanal Chem, 2009, 394(1): 245-54. PMCID:19277616.

Nyadong L, Harris GA, Balayssac S, Galhena AS, Malet-Martino M, Martino R, Parry RM, Wang MD, Fernandez FM, Gilard V. "Combining two-dimensional diffusion-ordered nuclear magnetic resonance spectroscopy, imaging desorption electrospray ionization mass spectrometry, and direct analysis in real-time mass spectrometry for the integral investigation of counterfeit pharmaceuticals". Anal Chem, 2009, 81(12): 4803-12. PMCID:19453162.

 Lane AL, Nyadong L, Galhena AS, Shearer TL, Stout EP, Parry RM, Kwasnik M, Wang MD, Hay ME, Fernandez FM, Kubanek J. "Desorption electrospray ionization mass spectrometry reveals surface-mediated antifungal chemical defense of a tropical seaweed". Proc Natl Acad Sci U S A, 2009, 106(18): 7314-9. PMCID:19366672.

 Siy PW, Moffitt RA, Parry RM, Chen YF, Liu Y, Sullards MC, Merrill AH, Wang MD. "Matrix Factorization Techniques for Analysis of Imaging Mass Spectrometry Data". 8th IEEE International Conference on Bioinformatics and Bioengineering, Vols 1 and 2, 2008: 875-80. PMCID:WOS:000263828500149.

Ricci C, Nyadong L, Fernandez FM, Newton PN, Kazarian SG. "Combined Fourier-transform infrared imaging and desorption electrospray-ionization linear ion-trap mass spectrometry for analysis of counterfeit antimalarial tablets". Anal Bioanal Chem, 2007, 387(2): 551-9. PMCID:17136340.

Muir ER, Ndiour IJ, Le Goasduff NA, Moffitt RA, Liu Y, Sullards MC, Merrill AH, Chen Y, Wang MD. "Multivariate analysis of imaging mass spectrometry data". Proceedings of the 7th IEEE International Symposium on Bioinformatics and Bioengineering, Vols I and Ii, 2007: 472-9.