Upcoming Events

Thursday, January 25, 2018

01:00 PM to 03:00 PM Thesis Defense - MoSE Room 3201A - Mr. Swe Htet Naing
Thesis Title: " Solution Structure and Biochemistry of an Intramembrane Aspartyl Protease (IAP)"
Committee Members: Prof. Raquel Lieberman (Advisor), School of Chemistry and Biochemistry Prof. Adegboyega (Yomi) Oyelere, School of Chemistry and Biochemistry Prof. Pamela Peralta-Yahya, School of Chemistry and Biochemistry Prof. Roger Wartell, School of Biological Sciences Prof. Loren Williams, School of Chemistry and Biochemistry
04:00 PM to 05:00 PM Colloquium - MoSE G011 - Prof. Neil Kelleher
"When Good Isoforms Go Bad - Mapping Mutation/Modification Cross Talk on KRAS4b in Colorectal Cancer"
Oncogenic mutations of KRAS are found in ~22% of human cancers and result in constitutive activation of downstream pathways. These pathways promote cell survival, proliferation and tumorigenesis, affecting cancer progression and treatment outcome. Here, we describe a new workflow that can quantify mutation-specific consequences of KRAS structure and biochemistry, such as linked changes in post-translational modifications (PTMs). We combined immunoaffinity enrichment with detection by top-down proteomics to map and quantify intact KRAS4b proteoforms with or without the Gly13Asp mutation (G13D). This seminar will focus on results from isogenic colorectal cancer (CRC) cell lines and then transition to patient CRC tumors with matching KRAS genotypes. In two cellular models, a direct link between the knock-out of the mutant G13D allele and nitrosylation of cysteine 118 of the remaining wild type KRAS4b was observed. Analysis of tumor samples quantified the percentage of mutant KRAS4b actually expressed in cancer tissue and identified major differences in C-terminal carboxymethylation known to be critical for membrane association. Switching from targeted to discovery modes, we will survey results from use of top-down proteomics in systems biology and for biomarker discovery in organ transplantation. Finally, a new "native" for top-down proteomics (i.e., "Native Proteomics") will be introduced, where the complete composition of endogenous protein complexes can be determined (Nat. Chem. Biol. 2017 Nov 13. doi: 10.1038/nchembio.2515).

Thursday, February 08, 2018

04:00 PM to 05:00 PM Colloquium - MoSE G011 - Prof Javier Read de Alanzi
Developing new transformations for stimuli-responsive materials
My research group is involved with a wide range of fundamental and applied chemistry that extends from the development of new synthetic transformations to the creation of a novel class of organic photochromic materials. In this lecture, the design, development and applications of negative photochromic systems will be presented. In addition, temperature tunable building blocks for efficient polymer modification will be discussed.

Tuesday, February 20, 2018

11:00 AM to 12:00 PM Meeting - MoSE 3201A - Faculty Meeting
No information available.

Thursday, February 22, 2018

04:00 PM to 05:00 PM Colloquium - MoSE G011 - Prof. Albrecht-Schmitt
"Hund's Rules are Merely Suggestions: What Happens when Relativity Monkeys Around with Electrons?"
No information available.

Thursday, March 01, 2018

11:00 AM to 12:00 PM Special Seminar - EST L1205 - Prof. Nita Sahai
Atmosphere-Water-Rock Interactions in Priming the Origins of Protocells
No information available.

Thursday, March 08, 2018

04:00 PM to 05:00 PM Cherry Emerson Seminar Series - MoSE G011 - Prof Neil Garg
TBD
TBD

Tuesday, March 20, 2018

11:00 AM to 12:00 PM Meeting - MoSE 3201A - Faculty Meeting
No information available.

Tuesday, March 27, 2018

11:00 AM to 12:00 PM Physical Division Seminar - MoSE 3201A - Prof Yan Yu
TBD
No information available.

Tuesday, April 03, 2018

11:00 AM to 12:00 PM Analytical Division Seminar - MoSE 3201A - Prof Amanda Hummon
TBD
No information available.

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