Vishal Patil

Personal Info

Contact

Education

  • Graduate: Georgia Tech '11 Ph.D. Organic Chemistry
  • Undergraduate: UICT Mumbai B.Tech. in Dyes Technology
Status
  • Post-doc.
Field
  • Synthetic organic chemistry

Projects

  • Novel Zinc Binding Groups for HDAC Inhibition



 

Bio

Vishal recently earned his Ph.D., and was with the Oyelere group from 2006-2011. He worked on HDAC inhibitors as anticancer agents. Vishal has performed molecular docking in silico analysis for many projects (his own and others') to corroborate in vitro results.

Publications

  • Chen, P. C.*; Patil, V.*; Guerrant, W.; Green, P.; Oyelere A. K. “Synthesis and structure activity relationship of histone deacetylase (HDAC) inhibitors with triazole-linked cap group” Bioorganic and medicinal chemistry 2008, 16(9), 4839-4853
  • Patil, V.*; Guerrant, W.*; Chen, P. C.; Gryder B., Benicewicz, D.; Khan, S.; Tekwani, B; Oyelere A. K. “ Antimalarial and antileishmanial activities of histone deacetylase inhibitors with triazole-linked cap group” Bioorganic and medicinal chemistry 2010, 18(1), 415-425.
  • Mwakwari, S. C., Guerrant W., Patil, V.; Khan, S.; Tekwani, B.; Gurard-Levin, Z.; Mrksich M.; Oyelere A. K.; “ Non-peptide Macrocyclic Histone Deacetylase Inhibitors Derived from Tricyclic Ketolide Skeleton” J. Med. Chem., 2010 Accepted.
  • Mwakwari, S. C.; Patil, V.; Guerrant, W.; Oyelere A. K. “Macrocyclic Histone Deacetylase Inhibitors” (review article) Current topics in medicinal chemistry, 2010, submitted

(* authors contributed equally)

Meetings & Symposia

  • Chen, P. C.**; Patil, V.; Guerrant, W.; Green, P.; Oyelere A. K. “Synthesis and structure activity relationship of histone deacetylase (HDAC) inhibitors with triazole-linked cap group” 235th ACS National Meeting, New Orleans , LA , April 6-10, 2008.
  • Patil, V.**, Guerrant, W.; Green P.; Verma M., Canzoneri J., Oyelere A. K. “Dual Acting Histone Deacetylas-Topoisomerase II Inhibitors” 236th ACS National Meeting, Philadelphia , PA August 17-21, 2008.
  • Hood R**; Guerrant W, Patil V, Yao D, Oyelere AK “Evaluating the Activity of Dual-Acting Histone Deacetylase (HDAC) Inhibitors’ 60th Southeastern Regional Meeting, Nashville, TN, November 12-15, 2008
  • Patil V**; Guerrant W, Canzoneri J, Oyelere AK “Structure Activity Relationship (SAR) of Dual Acting Histone Deacetylase-Topoisomerase II Inhibitors” 237th ACS National Meeting, Salt Lake City , UT , March 22-26, 2009.
  • Patil V**; Oyelere A. K. “Structure Assisted De Novo Design of Anti-leishmanial Agents” Structural Biology and Molecular Biophysics Symposium, Georgia Tech, Atlanta GA, July 24, 2009.
  • Patil V**.; Oyelere A. K.; Tekwani, B. “Design, synthesis, and SAR of small molecule inhibitors of the metalloprotease gp63 as novel antileishmanial agents” 239th ACS National Meeting, San Francisco , CA , March 21-25, 2010

(** presenting author)