Subhasish Tapadar

Personal Info

Contact:

Education:

  • Awarded with Ph.D. degree from Osmania University, India in the field of synthetic organic chemistry 2005
  • Undergraduate: BS in chemistry from University of Calcutta 1998

Current Status:

  • Research Scientist I

Field of Research:

  • Medicinal chemistry, drug discovery

Projects:

  • Synthesis of non-peptide macrocyclic HDAC inhibitors
  • Methodology development

 

Bio

Subhasish joined our group in May, 2011 and is pursuing research in drug discovery.

Publications

  1. Tapadar, S.; He, R; Luchini, D. N; Billadeau, D. D; Kozikowski, A. P; “Isooxazole Moiety in the Linker Region of HDAC Inhibitors Adjacent to the Zn-chelating Group: Effects in the HDAC Biology and Antiproliferative Activity” Bioorg. Org. Med. Chem. Lett. 2009, 19, 3023.
  2. Kozikowski, A. P; Chen, Y; Tapadar, S.; Lewin, N. E; Blumberg, P. M; Zhong, Z; Annibale, M. A. D; Wang, W; Shen, Y; Langley, B. C “Searching for Disease Modifiers – PKC Activities and HDAC Inhibition – A Dual Drug Approach to Alzheimer’s Disease that Reduces Aβ Production while Blocking Oxidative Stress” Chem. Med. Chem. 2009, 4,1095.
  3. Kozikowski, A. P.; Tapadar, S.; Savoy, D. N.; Billadeau, D. D.; Kim, K. H.; “Use of the Nitrile Oxide Cycloaddition (NOC) Reaction for Molecular Probe Generation- A New Class of Enzyme Selective Histone Deacetylase Inhibitors (HDACIs) Showing Picomolar Activity at HDAC6” J Med Chem 2008, 51, 4370.
  4. Tipparaju, S. k.; Mulhearn, D. C.; Klein, G. M.; Chen, Y.; Tapadar, S.; Bishop, M. H.; Yang, S.; Chen, J.; Ghassemi, M.; Santarsiero, B. D.; Cook, J. L.; Johlfs, M.; Mesecar, A. D.; Johnson, M. E.; and Kozikowski, A. P.; “Design and Synthesis of Novel Aryl Ether Inhibitors of the Bacillus Anthracis Enoyl–ACP Reductase” Chem Med Chem 2008, 3, 1250.
  5. Seo, Y. J.; Bhuniya, S.; Tapadar, S.; Yi, J. W.; Kim, B. H.; “Expanded Fluorescent Nucleoside Analogs as Hybridization Probe” Bull. Korean Chem. Soc. 2007, 28, 1923.
  6. Chakraborty, T. K.; Srinivasu, P.; Tapadar, S.; Bajjuri K. “Sugar amino acids in designing new molecules.” Glycoconjugate Journal 2005, 22, 83.
  7. Chakraborty, T. K.; Tapadar, S.; Roy, S. “Synthesis of 3,5-dihydroxy-2,4-dimethylheptanoic acid d-lactone in enantiomerically pure form.” ARKIVOC 2005, 3, 170.
  8. Singh, H.; Arora, K.; Tapadar, S.; Chakraborty, T. K. Preferential polymerization of 5-(aminomethyl)-2-furancarboxylic acid (AMFC) into a cyclic tripeptide. Journal of Theoretical & Computational Chemistry 2004, 3, 555.
  9. Chakraborty, T. K.; Tapadar, S.; Raju, T. V.; Annapurna, J; Singh, H. “Cyclic trimers of chiral furan amino acids.” Synlett 2004, 14, 2484.
  10. Chakraborty, T. K.; Srinivasu, P.; Tapadar, S.; Bajjuri K. “Sugar amino acids and related molecules: Some recent developments. Journal of Chemical Sciences 2004, 116, 187.
  11. Chakraborty, T. K.; Tapadar, S. “Synthesis of (+)-prelactone B. Tetrahedron Letters 2003, 44, 2541.
  12. Chakraborty, T. K.; Tapadar, S.; Kiran Kumar, S. “Cyclic trimer of 5-(aminomethyl)-2-furancarboxylic acid as a novel synthetic receptor for carboxylate recognition.” Tetrahedron Letters 2002, 43, 1317.
  13. Chakraborty, T. K.; Tapadar, S.; “Diastereoselective opening of trisubstituted epoxy alcohols: application in the synthesis of (+)-prelactone C.” Tetrahedron Letters 2001, 42, 1375.

PATENT: Chakraborty, T. K.; Tapadar, S. Synthesis of chiral furan amino acids as novel peptide building blocks. U.S. Pat. Appl. Publ. (2005), 20 pp. CODEN: USXXCO  US  2005222088  A1  20051006.