Publications

2013

Gryder, B. E.; Akbashev, M. J.; Rood, M. K.; Raftery, E. D.; Meyers, W. M.; Dillard, P.; Khan, S.; Oyelere, A. K.  Selectively Targeting Prostate Cancer with Antiandrogen Equipped Histone Deacetylase Inhibitors. ACS Chemical Biology, 2013 (Article ASAP). DOI: 10.1021/cb400542w.

*Gryder, B.E.; *Rood, M.K.; *Johnson, K.A.; Patil, V.; Raftery, E.D.; Yao, L.D.; Rice, M.; Azizi, B.; Doyle, D.F.; Oyelere, A.K., Histone Deacetylase Inhibitors Equipped with Estrogen Receptor Modulation Activity. Journal of Medicinal Chemistry 2013, 56, 5782−5796 (*= these authors contributed equally to this work), DOI: 10.1021/jm400467w

 

Guerrant, W.; Patil, V.; Canzoneri, J.; Hood, R.; Oyelere, A. K. Dual-acting histone deacetylase-topoisomerase I inhibitors Bioorg. Med. Chem. Lett. 2013, 23, 3283–3287. (article online)

Patil, V.; Sodji, Q.; Kornacki, J.; Mrksich, M.; Oyelere, A. K. 3-Hydroxypyridin-2-thiones as a novel zinc binding group for selective HDAC inhibition. J Med Chem 2013, 56, 3492−3506. DOI: 10.1021/jm301769u

jm-2012-01769u_0013

2012

Gryder, B.; Sodji,Q. H.; Oyelere, A. K. Targeted Cancer Therapy: Giving Histone Deacetylase Inhibitors All They Need to Succeed. Future Med. Chem. 2012, 4, 505-524. DOI: 10.4155/fmc.12.3

*Dreaden, E.C.; *Gryder, B.E.; Austin, L.A.; Tene Defo, B.A.; Hayden, S.C.; Pi, M.; Quarles, L.D.; Oyelere, A.K.; El-Sayed, M.A., Antiandrogen Gold Nanoparticles Dual-Target and Overcome Treatment Resistance in Hormone-Insensitive Prostate Cancer Cells Bioconjugate Chemistry 2012, (*= these authors contributed equally to this work) DOI: 10.1021/bc300158k

Patil, V.; Canzoneri, J. C.; Samatov, T. R.; Lührmann, R.; Oyelere, A. K. Molecular architecture of zinc chelating small molecules that inhibit spliceosome assembly at an early stage. RNA 2012, 18, 1605-1611. DOI: 10.1261/rna.034819.112

Dreaden, E. C.; Mwakwari, S. C.; Austin, L. A.; Kieffer, M. J.; Oyelere, A. K.; El-Sayed, M. A. Small Molecule-Gold Nanorod Conjugates Selectively Target and Induce Macrophage Cytotoxicity towards Breast Cancer Cells. Small 2012, 8, 2819-2822. DOI: 10.1002/smll.201200333

Guerrant, W.; Patil, V.; Canzoneri, J. C.; Oyelere, A. K. Dual Targeting of Histone Deacetylase and Topoisomerase II with Novel Bifunctional Inhibitors.  J. Med. Chem. 2012, 55, 1465−1477. DOI: 10.1021/jm200799p

2011

Gryder, B.; Guerrant, W.; Chen, C. H.; Oyelere, A. K. Oxathiazole-2-one derivative of bortezomib: Synthesis, stability and proteasome inhibition activity. Med. Chem. Comm. 2011, 2, 1083–1086 DOI: 10.1039/C1MD00208B

2010

Huang, X.; Kan, B.; Qian, W.; Chen, P. C.; Oyelere, A. K.; El-Sayed, I. H.; El-Sayed, M. A. Comparative study of photothermolysis of cancer cells with nuclear-targeted or cytoplasm-targeted gold nanospheres: continuous wave or pulsed lasers.  J. Biomed. Optics 2010, 15, 058002 DIO: 10.1117/1.3486538

Mwakwari, S. C.; Guerrant, W.; Patil, V.; Khan, S. I.; Tekwani, B. L.; Gurard-Levin, Z. A.; Mrksich, M.; Oyelere, A. K. Nonpeptide Macrocyclic Histone Deacetylase (HDAC) Inhibitors Derived from Tricyclic Ketolide.  J. Med. Chem. 2010, 53, 6100–6111 DIO: 10.1021/jm100507q

Mwakwari, S. C.; Patil, V.; Guerrant, W.; Oyelere, A. K. Macrocyclic Histone Deacetylase (HDAC) Inhibitors. Curr. Top. Med. Chem. 2010, 10, 1423-1440 DOI10.2174/156802610792232079

Oyelere, A. K. Macrocycles in Medicinal Chemistry and Drug Discovery (Editorial). Curr. Top. Med. Chem. 2010, 10, 1359-1360

Guerrant, W.; Mwakwari, S. C.; Chen, P. C.; Khan, S. I.; Tekwani, B. L.; Oyelere, A. K. A Structure Activity Relationship Study of the Antimalarial and Antileishmanial Activities of Non-peptide Macrocyclic Histone Deacetylase Inhibitors. ChemMedChem 2010, 5, 1232–1235 DOI: 10.1002/cmdc.201000087

Patil, V.; Guerrant, W.; Chen, P. C.; Gryder, B.; Benicewicz, D. B.; Khan, S. I.; Tekwani, B. L.; Oyelere, A. K. Antimalarial and Antileishmanial Activities of Histone Deacetylase (HDAC) Inhibitors with Triazole-Linked Cap Group. Bioorg. Med. Chem. 2010, 18, 415–425. DOI: 10.1016/j.bmc.2009.10.042

2009

Dreaden, E. C.; Mwakwari, S. C.; Sodji, Q. H.; Oyelere, A. K.; El-Sayed, M. A. Tamoxifen−Poly(ethylene glycol)−Thiol Gold Nanoparticle Conjugates: Enhanced Potency and Selective Delivery for Breast Cancer Treatment. Bioconjugate Chem, 2009, 20, 2247–2253. DOI: 10.1021/bc9002212

Canzoneri, J. C.; Chen, P. C.; Oyelere, A. K. Design and Synthesis of Novel Histone Deacetylase Inhibitor Derived from Nuclear Localization Signal Peptide. Bioorg. Med. Chem. Lett. 2009, 19, 6588–6590.*

Oyelere, A. K.; Chen, P. C.; Guerrant, W.; Mwakwari, S. C; Hood, R.; Zhang, Y.; Fan, Y. Nonpeptide Macrocyclic Histone Deacetylase (HDAC) Inhibitors. J. Med. Chem. 2009, 52, 456-468.*

2008

Canzoneri, J. C.; Oyelere, A. K. Interaction of Anthracyclines with Iron Responsive Element mRNAs. Nucleic Acids Res. 2008, 36, 6825–6834.*

Chen, P. C.; Mwakwari, S.; Oyelere, A. K. Gold Nanoparticles – From Nanomedicine to Nanosensing. Nanotechnology, Science and Applications, 2008, 1, 45-66.*

Chen, P. C.; Patil, V.; Guerrant, W.; Green, P.; Oyelere, A. K. Synthesis and Structure-Activity Relationship of Histone Deacetylase (HDAC) Inhibitors with Triazole-Linked Cap Group. Bioorg. Med. Chem. 2008, 16, 4839–4853.*

2007

Oyelere, A. K.; Chen, P. C.; Huang, X.; El-Sayed, I. H.; El-Sayed, M. A. Peptide-Conjugated Gold Nanorods for Nuclear Targeting. Bioconj. Chem. 2007, 18, 1490-1497 (one of the most-accessed articles published in Bioconjugate Chemistry in the 3rd quarter of 2007, Source: http://pubs.acs.org/journals/bcches/promo/most/most_accessed/index.html; Editor selected paper in imaging representing high quality, peer reviewed research published in Bioconjugate Chemistry).*

Chen, P. C.; Emrich, R. E.; Patel, P. A.; Oyelere, A. K. Direct Diazo-Transfer Reaction on β-lactam: Synthesis and Preliminary Biological Activities of 6-Triazolylpenicillanic Acids. Bioorg. Med. Chem. 2007, 15, 7288-7300.*

2006

Oyelere, A. K.; Chen, P. C.; Yao, L. P.; Boguslavsky, N. Heterogeneous Diazo-transfer Reaction: A Facile Unmasking of Azide Groups on Amine Functionalized Insoluble Supports for Solid Phase Synthesis. J. Org. Chem. 2006, 71, 9791-9796.*