Publications

Found 12 results
Filters: Keyword is Eye Proteins  [Clear All Filters]
2018
D. J. E. Huard and Lieberman, R. L., “Progress toward development of a proteostasis drug for myocilin-associated glaucoma.”, Future Med Chem, vol. 10, no. 12, pp. 1391-1393, 2018.
Y. Wang, Gao, Y., Hill, S. E., Huard, D. J. E., Tomlin, M. O., Lieberman, R. L., Paravastu, A. K., and Hall, C. K., “Simulations and Experiments Delineate Amyloid Fibrilization by Peptides Derived from Glaucoma-Associated Myocilin.”, J Phys Chem B, vol. 122, no. 22, pp. 5845-5850, 2018.
2014
A. R. Stothert, Suntharalingam, A., Huard, D. J. E., Fontaine, S. N., Crowley, V. M., Mishra, S., Blagg, B. S. J., Lieberman, R. L., and Dickey, C. A., “Exploiting the interaction between Grp94 and aggregated myocilin to treat glaucoma.”, Hum Mol Genet, vol. 23, no. 24, pp. 6470-80, 2014.
S. E. Hill, Donegan, R. K., and Lieberman, R. L., “The glaucoma-associated olfactomedin domain of myocilin forms polymorphic fibrils that are constrained by partial unfolding and peptide sequence.”, J Mol Biol, vol. 426, no. 4, pp. 921-35, 2014.
S. D. Orwig, Chi, P. V., Du, Y., Hill, S. E., Cavitt, M. A., Suntharalingam, A., Turnage, K. C., Dickey, C. A., France, S., Fu, H., and Lieberman, R. L., “Ligands for glaucoma-associated myocilin discovered by a generic binding assay.”, ACS Chem Biol, vol. 9, no. 2, pp. 517-25, 2014.
2012
S. D. Orwig, Perry, C. W., Kim, L. Y., Turnage, K. C., Zhang, R., Vollrath, D., Schmidt-Krey, I., and Lieberman, R. L., “Amyloid fibril formation by the glaucoma-associated olfactomedin domain of myocilin.”, J Mol Biol, vol. 421, no. 2-3, pp. 242-55, 2012.
R. K. Donegan, Hill, S. E., Turnage, K. C., Orwig, S. D., and Lieberman, R. L., “The glaucoma-associated olfactomedin domain of myocilin is a novel calcium binding protein.”, J Biol Chem, vol. 287, no. 52, pp. 43370-7, 2012.
A. Suntharalingam, Abisambra, J. F., O'Leary, J. C., Koren, J., Zhang, B., Joe, M. Kuk, Blair, L. J., Hill, S. E., Jinwal, U. K., Cockman, M., Duerfeldt, A. S., Tomarev, S., Blagg, B. S. J., Lieberman, R. L., and Dickey, C. A., “Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism.”, J Biol Chem, vol. 287, no. 48, pp. 40661-9, 2012.
R. K. Donegan and Lieberman, R. L., “New direction for glaucoma therapeutics: focus on the olfactomedin domain of myocilin.”, Future Med Chem, vol. 4, no. 17, pp. 2131-4, 2012.
2011
S. D. Orwig and Lieberman, R. L., “Biophysical characterization of the olfactomedin domain of myocilin, an extracellular matrix protein implicated in inherited forms of glaucoma.”, PLoS One, vol. 6, no. 1, p. e16347, 2011.
N. J Burns, Turnage, K. C., Walker, C. A., and Lieberman, R. L., “The stability of myocilin olfactomedin domain variants provides new insight into glaucoma as a protein misfolding disorder.”, Biochemistry, vol. 50, no. 26, pp. 5824-33, 2011.
2010
N. J Burns, Orwig, S. D., Harris, J. L., J Watkins, D., Vollrath, D., and Lieberman, R. L., “Rescue of glaucoma-causing mutant myocilin thermal stability by chemical chaperones.”, ACS Chem Biol, vol. 5, no. 5, pp. 477-87, 2010.