Publications

Found 8 results
Filters: Author is Orwig, Susan D  [Clear All Filters]
2015
R. K. Donegan, Hill, S. E., Freeman, D. M., Nguyen, E., Orwig, S. D., Turnage, K. C., and Lieberman, R. L., “Structural basis for misfolding in myocilin-associated glaucoma.”, Hum Mol Genet, vol. 24, no. 8, pp. 2111-24, 2015.
2014
S. D. Orwig, Chi, P. V., Du, Y., Hill, S. E., Cavitt, M. A., Suntharalingam, A., Turnage, K. C., Dickey, C. A., France, S., Fu, H., and Lieberman, R. L., “Ligands for glaucoma-associated myocilin discovered by a generic binding assay.”, ACS Chem Biol, vol. 9, no. 2, pp. 517-25, 2014.
2012
S. D. Orwig, Perry, C. W., Kim, L. Y., Turnage, K. C., Zhang, R., Vollrath, D., Schmidt-Krey, I., and Lieberman, R. L., “Amyloid fibril formation by the glaucoma-associated olfactomedin domain of myocilin.”, J Mol Biol, vol. 421, no. 2-3, pp. 242-55, 2012.
R. K. Donegan, Hill, S. E., Turnage, K. C., Orwig, S. D., and Lieberman, R. L., “The glaucoma-associated olfactomedin domain of myocilin is a novel calcium binding protein.”, J Biol Chem, vol. 287, no. 52, pp. 43370-7, 2012.
2011
S. D. Orwig, Tan, Y. Lei, Grimster, N. P., Yu, Z., Powers, E. T., Kelly, J. W., and Lieberman, R. L., “Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-β-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease.”, Biochemistry, vol. 50, no. 49, pp. 10647-57, 2011.
S. D. Orwig and Lieberman, R. L., “Biophysical characterization of the olfactomedin domain of myocilin, an extracellular matrix protein implicated in inherited forms of glaucoma.”, PLoS One, vol. 6, no. 1, p. e16347, 2011.
2010
N. J Burns, Orwig, S. D., Harris, J. L., J Watkins, D., Vollrath, D., and Lieberman, R. L., “Rescue of glaucoma-causing mutant myocilin thermal stability by chemical chaperones.”, ACS Chem Biol, vol. 5, no. 5, pp. 477-87, 2010.
2009
M. R. Landon, Lieberman, R. L., Hoang, Q. Q., Ju, S., Caaveiro, J. M. M., Orwig, S. D., Kozakov, D., Brenke, R., Chuang, G. - Y., Beglov, D., Vajda, S., Petsko, G. A., and Ringe, D., “Detection of ligand binding hot spots on protein surfaces via fragment-based methods: application to DJ-1 and glucocerebrosidase.”, J Comput Aided Mol Des, vol. 23, no. 8, pp. 491-500, 2009.