Found 27 results
Filters: Author is Lieberman, Raquel L  [Clear All Filters]
D. J. E. Huard and Lieberman, R. L., Progress toward development of a proteostasis drug for myocilin-associated glaucoma, Future Medicinal Chemistry, vol. 1031, no. 1210, pp. 1391 - 1393, 2018.
S. - H. Naing, Vukoti, K. M., Drury, J. E., Johnson, J. L., Kalyoncu, S., Hill, S. E., Torres, M. P., and Lieberman, R. L., Catalytic Properties of Intramembrane Aspartyl Protease Substrate Hydrolysis Evaluated Using a FRET Peptide Cleavage Assay., ACS Chem Biol, vol. 10, no. 9, pp. 2166-74, 2015.
R. K. Donegan and Lieberman, R. L., Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions., J Med Chem, 2015.
K. C. Entzminger, Johnson, J. L., Hyun, J., Lieberman, R. L., and Maynard, J. A., Increased Fab thermoresistance via VH-targeted directed evolution., Protein Eng Des Sel, vol. 28, no. 10, pp. 365-77, 2015.
S. E. Hill, Donegan, R. K., Nguyen, E., Desai, T. M., and Lieberman, R. L., Molecular Details of Olfactomedin Domains Provide Pathway to Structure-Function Studies., PLoS One, vol. 10, no. 6, p. e0130888, 2015.
J. L. Johnson, Entzminger, K. C., Hyun, J., Kalyoncu, S., Heaner, D. P., Morales, I. A., Sheppard, A., Gumbart, J. C., Maynard, J. A., and Lieberman, R. L., Structural and biophysical characterization of an epitope-specific engineered Fab fragment and complexation with membrane proteins: implications for co-crystallization., Acta Crystallogr D Biol Crystallogr, vol. 71, no. Pt 4, pp. 896-906, 2015.
R. K. Donegan, Hill, S. E., Freeman, D. M., Nguyen, E., Orwig, S. D., Turnage, K. C., and Lieberman, R. L., Structural basis for misfolding in myocilin-associated glaucoma., Hum Mol Genet, vol. 24, no. 8, pp. 2111-24, 2015.
S. D. Orwig, Tan, Y. Lei, Grimster, N. P., Yu, Z., Powers, E. T., Kelly, J. W., and Lieberman, R. L., Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-β-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease., Biochemistry, vol. 50, no. 49, pp. 10647-57, 2011.
S. D. Orwig and Lieberman, R. L., Biophysical characterization of the olfactomedin domain of myocilin, an extracellular matrix protein implicated in inherited forms of glaucoma., PLoS One, vol. 6, no. 1, p. e16347, 2011.
J. C. Pai, Culver, J. A., Drury, J. E., Motani, R. S., Lieberman, R. L., and Maynard, J. A., Conversion of scFv peptide-binding specificity for crystal chaperone development., Protein Eng Des Sel, vol. 24, no. 5, pp. 419-28, 2011.
R. L. Lieberman, Culver, J. A., Entzminger, K. C., Pai, J. C., and Maynard, J. A., Crystallization chaperone strategies for membrane proteins., Methods, vol. 55, no. 4, pp. 293-302, 2011.
R. L. Lieberman, A Guided Tour of the Structural Biology of Gaucher Disease: Acid-β-Glucosidase and Saposin C, Enzyme Research, vol. 2011, 2011.
R. L. Lieberman, Sneak peak at galactocerebrosidase, Krabbe disease's lysosomal hydrolase., Proc Natl Acad Sci U S A, vol. 108, no. 37, pp. 15017-8, 2011.
N. J Burns, Turnage, K. C., Walker, C. A., and Lieberman, R. L., The stability of myocilin olfactomedin domain variants provides new insight into glaucoma as a protein misfolding disorder., Biochemistry, vol. 50, no. 26, pp. 5824-33, 2011.