Publications

Found 26 results
Filters: Author is Lieberman, Raquel L  [Clear All Filters]
2016
V. M. Crowley, Khandelwal, A., Mishra, S., Stothert, A. R., Huard, D. J. E., Zhao, J., Muth, A., Duerfeldt, A. S., Kizziah, J. Lewis, Lieberman, R. L., Dickey, C. A., and Blagg, B. S. J., “Development of Glucose Regulated Protein 94-Selective Inhibitors based on the BnIm and Radamide Scaffold.”, J Med Chem, 2016.
2015
S. - H. Naing, Vukoti, K. M., Drury, J. E., Johnson, J. L., Kalyoncu, S., Hill, S. E., Torres, M. P., and Lieberman, R. L., “Catalytic Properties of Intramembrane Aspartyl Protease Substrate Hydrolysis Evaluated Using a FRET Peptide Cleavage Assay.”, ACS Chem Biol, vol. 10, no. 9, pp. 2166-74, 2015.
R. K. Donegan and Lieberman, R. L., “Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions.”, J Med Chem, 2015.
K. C. Entzminger, Johnson, J. L., Hyun, J., Lieberman, R. L., and Maynard, J. A., “Increased Fab thermoresistance via VH-targeted directed evolution.”, Protein Eng Des Sel, vol. 28, no. 10, pp. 365-77, 2015.
S. E. Hill, Donegan, R. K., Nguyen, E., Desai, T. M., and Lieberman, R. L., “Molecular Details of Olfactomedin Domains Provide Pathway to Structure-Function Studies.”, PLoS One, vol. 10, no. 6, p. e0130888, 2015.
J. L. Johnson, Entzminger, K. C., Hyun, J., Kalyoncu, S., Heaner, D. P., Morales, I. A., Sheppard, A., Gumbart, J. C., Maynard, J. A., and Lieberman, R. L., “Structural and biophysical characterization of an epitope-specific engineered Fab fragment and complexation with membrane proteins: implications for co-crystallization.”, Acta Crystallogr D Biol Crystallogr, vol. 71, no. Pt 4, pp. 896-906, 2015.
R. K. Donegan, Hill, S. E., Freeman, D. M., Nguyen, E., Orwig, S. D., Turnage, K. C., and Lieberman, R. L., “Structural basis for misfolding in myocilin-associated glaucoma.”, Hum Mol Genet, vol. 24, no. 8, pp. 2111-24, 2015.
2014
A. R. Stothert, Suntharalingam, A., Huard, D. J. E., Fontaine, S. N., Crowley, V. M., Mishra, S., Blagg, B. S. J., Lieberman, R. L., and Dickey, C. A., “Exploiting the interaction between Grp94 and aggregated myocilin to treat glaucoma.”, Hum Mol Genet, vol. 23, no. 24, pp. 6470-80, 2014.
S. E. Hill, Donegan, R. K., and Lieberman, R. L., “The glaucoma-associated olfactomedin domain of myocilin forms polymorphic fibrils that are constrained by partial unfolding and peptide sequence.”, J Mol Biol, vol. 426, no. 4, pp. 921-35, 2014.
S. D. Orwig, Chi, P. V., Du, Y., Hill, S. E., Cavitt, M. A., Suntharalingam, A., Turnage, K. C., Dickey, C. A., France, S., Fu, H., and Lieberman, R. L., “Ligands for glaucoma-associated myocilin discovered by a generic binding assay.”, ACS Chem Biol, vol. 9, no. 2, pp. 517-25, 2014.
Y. Yu, Mena-Barragán, T., Higaki, K., Johnson, J. L., Drury, J. E., Lieberman, R. L., Nakasone, N., Ninomiya, H., Tsukimura, T., Sakuraba, H., Suzuki, Y., Nanba, E., Mellet, C. Ortiz, Fernández, J. M. García, and Ohno, K., “Molecular basis of 1-deoxygalactonojirimycin arylthiourea binding to human α-galactosidase a: pharmacological chaperoning efficacy on Fabry disease mutants.”, ACS Chem Biol, vol. 9, no. 7, pp. 1460-9, 2014.
2013
R. L. Lieberman, Peek, M. E., and J Watkins, D., “Determination of soluble and membrane protein structures by X-ray crystallography.”, Methods Mol Biol, vol. 955, pp. 475-93, 2013.
2012
S. D. Orwig, Perry, C. W., Kim, L. Y., Turnage, K. C., Zhang, R., Vollrath, D., Schmidt-Krey, I., and Lieberman, R. L., “Amyloid fibril formation by the glaucoma-associated olfactomedin domain of myocilin.”, J Mol Biol, vol. 421, no. 2-3, pp. 242-55, 2012.
R. K. Donegan, Hill, S. E., Turnage, K. C., Orwig, S. D., and Lieberman, R. L., “The glaucoma-associated olfactomedin domain of myocilin is a novel calcium binding protein.”, J Biol Chem, vol. 287, no. 52, pp. 43370-7, 2012.
A. Suntharalingam, Abisambra, J. F., O'Leary, J. C., Koren, J., Zhang, B., Joe, M. Kuk, Blair, L. J., Hill, S. E., Jinwal, U. K., Cockman, M., Duerfeldt, A. S., Tomarev, S., Blagg, B. S. J., Lieberman, R. L., and Dickey, C. A., “Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism.”, J Biol Chem, vol. 287, no. 48, pp. 40661-9, 2012.
R. K. Donegan and Lieberman, R. L., “New direction for glaucoma therapeutics: focus on the olfactomedin domain of myocilin.”, Future Med Chem, vol. 4, no. 17, pp. 2131-4, 2012.
2011
S. D. Orwig, Tan, Y. Lei, Grimster, N. P., Yu, Z., Powers, E. T., Kelly, J. W., and Lieberman, R. L., “Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-β-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease.”, Biochemistry, vol. 50, no. 49, pp. 10647-57, 2011.
S. D. Orwig and Lieberman, R. L., “Biophysical characterization of the olfactomedin domain of myocilin, an extracellular matrix protein implicated in inherited forms of glaucoma.”, PLoS One, vol. 6, no. 1, p. e16347, 2011.
J. C. Pai, Culver, J. A., Drury, J. E., Motani, R. S., Lieberman, R. L., and Maynard, J. A., “Conversion of scFv peptide-binding specificity for crystal chaperone development.”, Protein Eng Des Sel, vol. 24, no. 5, pp. 419-28, 2011.
R. L. Lieberman, Culver, J. A., Entzminger, K. C., Pai, J. C., and Maynard, J. A., “Crystallization chaperone strategies for membrane proteins.”, Methods, vol. 55, no. 4, pp. 293-302, 2011.
R. L. Lieberman, “A Guided Tour of the Structural Biology of Gaucher Disease: Acid-β-Glucosidase and Saposin C”, Enzyme Research, vol. 2011, 2011.
R. L. Lieberman, “Sneak peak at galactocerebrosidase, Krabbe disease's lysosomal hydrolase.”, Proc Natl Acad Sci U S A, vol. 108, no. 37, pp. 15017-8, 2011.
N. J Burns, Turnage, K. C., Walker, C. A., and Lieberman, R. L., “The stability of myocilin olfactomedin domain variants provides new insight into glaucoma as a protein misfolding disorder.”, Biochemistry, vol. 50, no. 26, pp. 5824-33, 2011.
2010
N. J Burns, Orwig, S. D., Harris, J. L., J Watkins, D., Vollrath, D., and Lieberman, R. L., “Rescue of glaucoma-causing mutant myocilin thermal stability by chemical chaperones.”, ACS Chem Biol, vol. 5, no. 5, pp. 477-87, 2010.
2009
M. R. Landon, Lieberman, R. L., Hoang, Q. Q., Ju, S., Caaveiro, J. M. M., Orwig, S. D., Kozakov, D., Brenke, R., Chuang, G. - Y., Beglov, D., Vajda, S., Petsko, G. A., and Ringe, D., “Detection of ligand binding hot spots on protein surfaces via fragment-based methods: application to DJ-1 and glucocerebrosidase.”, J Comput Aided Mol Des, vol. 23, no. 8, pp. 491-500, 2009.

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