Publications

Found 38 results
Filters: Author is Lieberman, Raquel L  [Clear All Filters]
2020
X. Liu, Zhao, J., Zhang, Y., Ubarretxena-Belandia, I., Forth, S., Lieberman, R. L., and Wang, C., “Substrate-Enzyme Interactions in Intramembrane Proteolysis: γ-Secretase as the Prototype.”, Front Mol Neurosci, vol. 13, p. 65, 2020.
2019
A. C. Patterson-Orazem and Lieberman, R. L., “Antibodies Used to Detect Glaucoma-Associated Myocilin: More or Less Than Meets the Eye?”, Invest Ophthalmol Vis Sci, vol. 60, no. 6, pp. 2034-2037, 2019.
A. C. Patterson-Orazem, Hill, S. E., Wang, Y., Dominic, I. M., Hall, C. K., and Lieberman, R. L., “Differential Misfolding Properties of Glaucoma-Associated Olfactomedin Domains from Humans and Mice.”, Biochemistry, vol. 58, no. 13, pp. 1718-1727, 2019.
M. Martínez-Bailén, Carmona, A. T., Patterson-Orazem, A. C., Lieberman, R. L., Ide, D., Kubo, M., Kato, A., Robina, I., and Moreno-Vargas, A. J., “Exploring substituent diversity on pyrrolidine-aryltriazole iminosugars: Structural basis of β-glucocerebrosidase inhibition.”, Bioorg Chem, vol. 86, pp. 652-664, 2019.
R. L. Lieberman, “How does a protein's structure spell the difference between health and disease? Our journey to understand glaucoma-associated myocilin.”, PLoS Biol, vol. 17, no. 4, p. e3000237, 2019.
X. Zhou, Paushter, D. H., Pagan, M. D., Kim, D., Santos, M. Nunez, Lieberman, R. L., Overkleeft, H. S., Sun, Y., Smolka, M. B., and Hu, F., “Progranulin deficiency leads to reduced glucocerebrosidase activity.”, PLoS One, vol. 14, no. 7, p. e0212382, 2019.
S. E. Hill, Kwon, M. S., Martin, M. D., Suntharalingam, A., Hazel, A., Dickey, C. A., Gumbart, J. C., and Lieberman, R. L., “Stable calcium-free myocilin olfactomedin domain variants reveal challenges in differentiating between benign and glaucoma-causing mutations.”, J Biol Chem, 2019.
2018
D. J. E. Huard, Demissie, A., Kim, D., Lewis, D., Dickson, R. M., Petty, J. T., and Lieberman, R. L., “Atomic structure of a fluorescent Ag cluster templated by a multi-stranded DNA scaffold.”, J Am Chem Soc, 2018.
K. E. Keller, Bhattacharya, S. K., Borrás, T., Brunner, T. M., Chansangpetch, S., Clark, A. F., W Dismuke, M., Du, Y., Elliott, M. H., C Ethier, R., Faralli, J. A., Freddo, T. F., Fuchshofer, R., Giovingo, M., Gong, H., Gonzalez, P., Huang, A., Johnstone, M. A., Kaufman, P. L., Kelley, M. J., Knepper, P. A., Kopczynski, C. C., Kuchtey, J. G., Kuchtey, R. W., Kuehn, M. H., Lieberman, R. L., Lin, S. C., Liton, P., Liu, Y., Lütjen-Drecoll, E., Mao, W., Masis-Solano, M., McDonnell, F., McDowell, C. M., Overby, D. R., Pattabiraman, P. P., Raghunathan, V. K., P Rao, V., Rhee, D. J., Chowdhury, U. Roy, Russell, P., Samples, J. R., Schwartz, D., Stubbs, E. B., Tamm, E. R., Tan, J. C., Toris, C. B., Torrejon, K. Y., Vranka, J. A., Wirtz, M. K., Yorio, T., Zhang, J., Zode, G. S., Fautsch, M. P., Peters, D. M., Acott, T. S., and W Stamer, D., “Consensus recommendations for trabecular meshwork cell isolation, characterization and culture.”, Exp Eye Res, vol. 171, pp. 164-173, 2018.
R. C. Oliver, Naing, S. - H., Weiss, K. L., Pingali, S. Venkatesh, Lieberman, R. L., and Urban, V. S., “Contrast-Matching Detergent in Small-Angle Neutron Scattering Experiments for Membrane Protein Structural Analysis and Ab Initio Modeling.”, J Vis Exp, no. 140, 2018.
D. J. E. Huard and Lieberman, R. L., “Progress toward development of a proteostasis drug for myocilin-associated glaucoma.”, Future Med Chem, vol. 10, no. 12, pp. 1391-1393, 2018.
Y. Wang, Gao, Y., Hill, S. E., Huard, D. J. E., Tomlin, M. O., Lieberman, R. L., Paravastu, A. K., and Hall, C. K., “Simulations and Experiments Delineate Amyloid Fibrilization by Peptides Derived from Glaucoma-Associated Myocilin.”, J Phys Chem B, vol. 122, no. 22, pp. 5845-5850, 2018.
2016
V. M. Crowley, Khandelwal, A., Mishra, S., Stothert, A. R., Huard, D. J. E., Zhao, J., Muth, A., Duerfeldt, A. S., Kizziah, J. Lewis, Lieberman, R. L., Dickey, C. A., and Blagg, B. S. J., “Development of Glucose Regulated Protein 94-Selective Inhibitors based on the BnIm and Radamide Scaffold.”, J Med Chem, 2016.
2015
S. - H. Naing, Vukoti, K. M., Drury, J. E., Johnson, J. L., Kalyoncu, S., Hill, S. E., Torres, M. P., and Lieberman, R. L., “Catalytic Properties of Intramembrane Aspartyl Protease Substrate Hydrolysis Evaluated Using a FRET Peptide Cleavage Assay.”, ACS Chem Biol, vol. 10, no. 9, pp. 2166-74, 2015.
R. K. Donegan and Lieberman, R. L., “Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions.”, J Med Chem, 2015.
K. C. Entzminger, Johnson, J. L., Hyun, J., Lieberman, R. L., and Maynard, J. A., “Increased Fab thermoresistance via VH-targeted directed evolution.”, Protein Eng Des Sel, vol. 28, no. 10, pp. 365-77, 2015.
S. E. Hill, Donegan, R. K., Nguyen, E., Desai, T. M., and Lieberman, R. L., “Molecular Details of Olfactomedin Domains Provide Pathway to Structure-Function Studies.”, PLoS One, vol. 10, no. 6, p. e0130888, 2015.
J. L. Johnson, Entzminger, K. C., Hyun, J., Kalyoncu, S., Heaner, D. P., Morales, I. A., Sheppard, A., Gumbart, J. C., Maynard, J. A., and Lieberman, R. L., “Structural and biophysical characterization of an epitope-specific engineered Fab fragment and complexation with membrane proteins: implications for co-crystallization.”, Acta Crystallogr D Biol Crystallogr, vol. 71, no. Pt 4, pp. 896-906, 2015.
R. K. Donegan, Hill, S. E., Freeman, D. M., Nguyen, E., Orwig, S. D., Turnage, K. C., and Lieberman, R. L., “Structural basis for misfolding in myocilin-associated glaucoma.”, Hum Mol Genet, vol. 24, no. 8, pp. 2111-24, 2015.
2014
A. R. Stothert, Suntharalingam, A., Huard, D. J. E., Fontaine, S. N., Crowley, V. M., Mishra, S., Blagg, B. S. J., Lieberman, R. L., and Dickey, C. A., “Exploiting the interaction between Grp94 and aggregated myocilin to treat glaucoma.”, Hum Mol Genet, vol. 23, no. 24, pp. 6470-80, 2014.
S. E. Hill, Donegan, R. K., and Lieberman, R. L., “The glaucoma-associated olfactomedin domain of myocilin forms polymorphic fibrils that are constrained by partial unfolding and peptide sequence.”, J Mol Biol, vol. 426, no. 4, pp. 921-35, 2014.
S. D. Orwig, Chi, P. V., Du, Y., Hill, S. E., Cavitt, M. A., Suntharalingam, A., Turnage, K. C., Dickey, C. A., France, S., Fu, H., and Lieberman, R. L., “Ligands for glaucoma-associated myocilin discovered by a generic binding assay.”, ACS Chem Biol, vol. 9, no. 2, pp. 517-25, 2014.
Y. Yu, Mena-Barragán, T., Higaki, K., Johnson, J. L., Drury, J. E., Lieberman, R. L., Nakasone, N., Ninomiya, H., Tsukimura, T., Sakuraba, H., Suzuki, Y., Nanba, E., Mellet, C. Ortiz, Fernández, J. M. García, and Ohno, K., “Molecular basis of 1-deoxygalactonojirimycin arylthiourea binding to human α-galactosidase a: pharmacological chaperoning efficacy on Fabry disease mutants.”, ACS Chem Biol, vol. 9, no. 7, pp. 1460-9, 2014.
2013
R. L. Lieberman, Peek, M. E., and J Watkins, D., “Determination of soluble and membrane protein structures by X-ray crystallography.”, Methods Mol Biol, vol. 955, pp. 475-93, 2013.
2012
S. D. Orwig, Perry, C. W., Kim, L. Y., Turnage, K. C., Zhang, R., Vollrath, D., Schmidt-Krey, I., and Lieberman, R. L., “Amyloid fibril formation by the glaucoma-associated olfactomedin domain of myocilin.”, J Mol Biol, vol. 421, no. 2-3, pp. 242-55, 2012.

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