Found 56 results
A. C. Patterson-Orazem and Lieberman, R. L., Antibodies Used to Detect Glaucoma-Associated Myocilin: More or Less Than Meets the Eye?, Invest Ophthalmol Vis Sci, vol. 60, no. 6, pp. 2034-2037, 2019.
S. E. Hill, Cho, H., Raut, P., and Lieberman, R. L., Calcium-ligand variants of the myocilin olfactomedin propeller selected from invertebrate phyla reveal cross-talk with N-terminal blade and surface helices, Acta Crystallographica Section D Structural Biology, vol. 75, no. 9, pp. 817 - 824, 2019.
D. J. E. Huard, Jonke, A. P., Torres, M. P., and Lieberman, R. L., Different Grp94 components interact transiently with the myocilin olfactomedin domain in vitro to enhance or retard its amyloid aggregation, Scientific Reports, vol. 9, no. 1, 2019.
A. C. Patterson-Orazem, Hill, S. E., Wang, Y., Dominic, I. M., Hall, C. K., and Lieberman, R. L., Differential Misfolding Properties of Glaucoma-Associated Olfactomedin Domains from Humans and Mice., Biochemistry, vol. 58, no. 13, pp. 1718-1727, 2019.
M. Martínez-Bailén, Carmona, A. T., Patterson-Orazem, A. C., Lieberman, R. L., Ide, D., Kubo, M., Kato, A., Robina, I., and Moreno-Vargas, A. J., Exploring substituent diversity on pyrrolidine-aryltriazole iminosugars: Structural basis of β-glucocerebrosidase inhibition., Bioorg Chem, vol. 86, pp. 652-664, 2019.
R. L. Lieberman, How does a protein's structure spell the difference between health and disease? Our journey to understand glaucoma-associated myocilin., PLoS Biol, vol. 17, no. 4, p. e3000237, 2019.
X. Zhou, Paushter, D. H., Pagan, M. D., Kim, D., Santos, M. Nunez, Lieberman, R. L., Overkleeft, H. S., Sun, Y., Smolka, M. B., and Hu, F., Progranulin deficiency leads to reduced glucocerebrosidase activity., PLoS One, vol. 14, no. 7, p. e0212382, 2019.
S. E. Hill, Kwon, M. S., Martin, M. D., Suntharalingam, A., Hazel, A., Dickey, C. A., Gumbart, J. C., and Lieberman, R. L., Stable calcium-free myocilin olfactomedin domain variants reveal challenges in differentiating between benign and glaucoma-causing mutations., J Biol Chem, 2019.
D. J. E. Huard, Demissie, A., Kim, D., Lewis, D., Dickson, R. M., Petty, J. T., and Lieberman, R. L., Atomic structure of a fluorescent Ag cluster templated by a multi-stranded DNA scaffold., J Am Chem Soc, 2018.
S. - H. Naing, Kalyoncu, S., Smalley, D. M., Kim, H., Tao, X., George, J. B., Jonke, A. P., Oliver, R. C., Urban, V. S., Torres, M. P., and Lieberman, R. L., Both positional and chemical variables control in vitro proteolytic cleavage of a presenilin ortholog, Journal of Biological Chemistry, vol. 29353, no. 13, pp. 4653 - 4663, 2018.
K. E. Keller, Bhattacharya, S. K., Borrás, T., Brunner, T. M., Chansangpetch, S., Clark, A. F., W Dismuke, M., Du, Y., Elliott, M. H., C Ethier, R., Faralli, J. A., Freddo, T. F., Fuchshofer, R., Giovingo, M., Gong, H., Gonzalez, P., Huang, A., Johnstone, M. A., Kaufman, P. L., Kelley, M. J., Knepper, P. A., Kopczynski, C. C., Kuchtey, J. G., Kuchtey, R. W., Kuehn, M. H., Lieberman, R. L., Lin, S. C., Liton, P., Liu, Y., Lütjen-Drecoll, E., Mao, W., Masis-Solano, M., McDonnell, F., McDowell, C. M., Overby, D. R., Pattabiraman, P. P., Raghunathan, V. K., P Rao, V., Rhee, D. J., Chowdhury, U. Roy, Russell, P., Samples, J. R., Schwartz, D., Stubbs, E. B., Tamm, E. R., Tan, J. C., Toris, C. B., Torrejon, K. Y., Vranka, J. A., Wirtz, M. K., Yorio, T., Zhang, J., Zode, G. S., Fautsch, M. P., Peters, D. M., Acott, T. S., and W Stamer, D., Consensus recommendations for trabecular meshwork cell isolation, characterization and culture., Exp Eye Res, vol. 171, pp. 164-173, 2018.
R. C. Oliver, Naing, S. - H., Weiss, K. L., Pingali, S. Venkatesh, Lieberman, R. L., and Urban, V. S., Contrast-Matching Detergent in Small-Angle Neutron Scattering Experiments for Membrane Protein Structural Analysis and Ab Initio Modeling., J Vis Exp, no. 140, 2018.
A. C. Patterson-Orazem, Hill, S. E., Fautsch, M. P., and Lieberman, R. L., Epitope mapping of commercial antibodies that detect myocilin, Experimental Eye Research, vol. 173, pp. 109 - 112, 2018.
R. Ashkar, Bilheux, H. Z., Bordallo, H., Briber, R., Callaway, D. J. E., Cheng, X., Chu, X. Qiang, Curtis, J. E., Dadmun, M., Fenimore, P., Fushman, D., Gabel, F., Gupta, K., Herberle, F., Heinrich, F., Hong, L., Katsaras, J., Kelman, Z., Kharlampieva, E., Kneller, G. R., Kovalevsky, A., Krueger, S., Langan, P., Lieberman, R., Liu, Y., Losche, M., Lyman, E., Mao, Y., Marino, J., Mattos, C., Meilleur, F., Moody, P., Nickels, J. D., O'Dell, W. B., O'Neill, H., Perez-Salas, U., Peters, J., Petridis, L., Sokolov, A. P., Stanley, C., Wagner, N., Weinrich, M., Weiss, K., Wymore, T., Zhang, Y., and Smith, J. C., Neutron scattering in the biological sciences: progress and prospects., Acta Crystallogr D Struct Biol, vol. 74, no. Pt 12, pp. 1129-1168, 2018.
D. J. E. Huard and Lieberman, R. L., Progress toward development of a proteostasis drug for myocilin-associated glaucoma., Future Med Chem, vol. 10, no. 12, pp. 1391-1393, 2018.
Y. Wang, Gao, Y., Hill, S. E., Huard, D. J. E., Tomlin, M. O., Lieberman, R. L., Paravastu, A. K., and Hall, C. K., Simulations and Experiments Delineate Amyloid Fibrilization by Peptides Derived from Glaucoma-Associated Myocilin., J Phys Chem B, vol. 122, no. 22, pp. 5845-5850, 2018.
S. - H. Naing, Oliver, R. C., Weiss, K. L., Urban, V. S., and Lieberman, R. L., Solution Structure of an Intramembrane Aspartyl Protease via Small Angle Neutron Scattering, Biophysical Journal, vol. 114, no. 3, pp. 602 - 608, 2018.
D. J. E. Huard, Crowley, V. M., Du, Y., Cordova, R. A., Sun, Z., Tomlin, M. O., Dickey, C. A., Koren, J., Blair, L., Fu, H., Blagg, B. S. J., and Lieberman, R. L., Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma, ACS Chemical Biology, vol. 13, no. 4, pp. 933 - 941, 2018.
K. C. Entzminger, Hyun, J. -min, Pantazes, R. J., Patterson-Orazem, A. C., Qerqez, A. N., Frye, Z. P., Hughes, R. A., Ellington, A. D., Lieberman, R. L., Maranas, C. D., and Maynard, J. A., De novo design of antibody complementarity determining regions binding a FLAG tetra-peptide, Sci. Rep., vol. 7, no. 1, 2017.
A. R. Stothert, Suntharalingam, A., Tang, X., Crowley, V. M., Mishra, S. J., Webster, J. M., Nordhues, B. A., Huard, D. J. E., Passaglia, C. L., Lieberman, R. L., Blagg, B. S. J., Blair, L. J., Koren, J., and Dickey, C. A., Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma, Sci. Rep., vol. 7, no. 1, 2017.
S. E. Hill, Nguyen, E., Ukachukwu, C. U., Freeman, D. M., Quirk, S., and Lieberman, R. L., Metal ion coordination in the E. coli Nudix hydrolase dihydroneopterin triphosphate pyrophosphatase: New clues into catalytic mechanism, PLoS One, vol. 12, no. 7, 2017.
M. Kuk Joe, Lieberman, R. L., Nakaya, N., and Tomarev, S. I., Myocilin regulates metalloprotease 2 activity through interaction with TIMP3, Invest. Ophthalmol. Vis. , vol. 58, no. 12, pp. 5308-5318, 2017.
V. M. Crowley, Huard, D. J. E., Lieberman, R. L., and Blagg, B. S. J., Second Generation Grp94‐Selective Inhibitors Provide Opportunities for the Inhibition of Metastatic Cancer, Chem. Eur. J, vol. 23, no. 62, pp. 15775-15782, 2017.
S. E. Hill, Nguyen, E., Donegan, R. K., Patterson-Orazem, A. C., Hazel, A., Gumbart, J. C., and Lieberman, R. L., Structure and Misfolding of the Flexible Tripartite Coiled-Coil Domain of Glaucoma-Associated Myocilin, Structure, vol. 25, no. 11, pp. 1697-1707. e5, 2017.