Found 43 results
S. - H. Naing, Kalyoncu, S., Smalley, D. M., Kim, H., Tao, X., George, J. B., Jonke, A. P., Oliver, R. C., Urban, V. S., Torres, M. P., and Lieberman, R. L., Both positional and chemical variables control in vitro proteolytic cleavage of a presenilin ortholog, Journal of Biological Chemistry, vol. 29353, no. 13, pp. 4653 - 4663, 2018.
A. C. Patterson-Orazem, Hill, S. E., Fautsch, M. P., and Lieberman, R. L., Epitope mapping of commercial antibodies that detect myocilin, Experimental Eye Research, vol. 173, pp. 109 - 112, 2018.
D. J. E. Huard and Lieberman, R. L., Progress toward development of a proteostasis drug for myocilin-associated glaucoma, Future Medicinal Chemistry, vol. 1031, no. 1210, pp. 1391 - 1393, 2018.
Y. Wang, Gao, Y., Hill, S. E., Huard, D. J. E., Tomlin, M. O., Lieberman, R. L., Paravastu, A. K., and Hall, C. K., Simulations and Experiments Delineate Amyloid Fibrilization by Peptides Derived from Glaucoma-Associated Myocilin, The Journal of Physical Chemistry B, vol. 122, no. 22, pp. 5845 - 5850, 2018.
S. - H. Naing, Oliver, R. C., Weiss, K. L., Urban, V. S., and Lieberman, R. L., Solution Structure of an Intramembrane Aspartyl Protease via Small Angle Neutron Scattering, Biophysical Journal, vol. 114, no. 3, pp. 602 - 608, 2018.
D. J. E. Huard, Crowley, V. M., Du, Y., Cordova, R. A., Sun, Z., Tomlin, M. O., Dickey, C. A., Koren, J., Blair, L., Fu, H., Blagg, B. S. J., and Lieberman, R. L., Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma, ACS Chemical Biology, vol. 13, no. 4, pp. 933 - 941, 2018.
K. C. Entzminger, Hyun, J. -min, Pantazes, R. J., Patterson-Orazem, A. C., Qerqez, A. N., Frye, Z. P., Hughes, R. A., Ellington, A. D., Lieberman, R. L., Maranas, C. D., and Maynard, J. A., De novo design of antibody complementarity determining regions binding a FLAG tetra-peptide, Sci. Rep., vol. 7, no. 1, 2017.
A. R. Stothert, Suntharalingam, A., Tang, X., Crowley, V. M., Mishra, S. J., Webster, J. M., Nordhues, B. A., Huard, D. J. E., Passaglia, C. L., Lieberman, R. L., Blagg, B. S. J., Blair, L. J., Koren, J., and Dickey, C. A., Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma, Sci. Rep., vol. 7, no. 1, 2017.
S. E. Hill, Nguyen, E., Ukachukwu, C. U., Freeman, D. M., Quirk, S., and Lieberman, R. L., Metal ion coordination in the E. coli Nudix hydrolase dihydroneopterin triphosphate pyrophosphatase: New clues into catalytic mechanism, PLoS One, vol. 12, no. 7, 2017.
M. Kuk Joe, Lieberman, R. L., Nakaya, N., and Tomarev, S. I., Myocilin regulates metalloprotease 2 activity through interaction with TIMP3, Invest. Ophthalmol. Vis. , vol. 58, no. 12, pp. 5308-5318, 2017.
V. M. Crowley, Huard, D. J. E., Lieberman, R. L., and Blagg, B. S. J., Second Generation Grp94‐Selective Inhibitors Provide Opportunities for the Inhibition of Metastatic Cancer, Chem. Eur. J, vol. 23, no. 62, pp. 15775-15782, 2017.
S. E. Hill, Nguyen, E., Donegan, R. K., Patterson-Orazem, A. C., Hazel, A., Gumbart, J. C., and Lieberman, R. L., Structure and Misfolding of the Flexible Tripartite Coiled-Coil Domain of Glaucoma-Associated Myocilin, Structure, vol. 25, no. 11, pp. 1697-1707. e5, 2017.
S. - H. Naing, Vukoti, K. M., Drury, J. E., Johnson, J. L., Kalyoncu, S., Hill, S. E., Torres, M. P., and Lieberman, R. L., Catalytic Properties of Intramembrane Aspartyl Protease Substrate Hydrolysis Evaluated Using a FRET Peptide Cleavage Assay., ACS Chem Biol, vol. 10, no. 9, pp. 2166-74, 2015.
R. K. Donegan and Lieberman, R. L., Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions., J Med Chem, 2015.
K. C. Entzminger, Johnson, J. L., Hyun, J., Lieberman, R. L., and Maynard, J. A., Increased Fab thermoresistance via VH-targeted directed evolution., Protein Eng Des Sel, vol. 28, no. 10, pp. 365-77, 2015.
S. E. Hill, Donegan, R. K., Nguyen, E., Desai, T. M., and Lieberman, R. L., Molecular Details of Olfactomedin Domains Provide Pathway to Structure-Function Studies., PLoS One, vol. 10, no. 6, p. e0130888, 2015.
J. L. Johnson, Entzminger, K. C., Hyun, J., Kalyoncu, S., Heaner, D. P., Morales, I. A., Sheppard, A., Gumbart, J. C., Maynard, J. A., and Lieberman, R. L., Structural and biophysical characterization of an epitope-specific engineered Fab fragment and complexation with membrane proteins: implications for co-crystallization., Acta Crystallogr D Biol Crystallogr, vol. 71, no. Pt 4, pp. 896-906, 2015.
R. K. Donegan, Hill, S. E., Freeman, D. M., Nguyen, E., Orwig, S. D., Turnage, K. C., and Lieberman, R. L., Structural basis for misfolding in myocilin-associated glaucoma., Hum Mol Genet, vol. 24, no. 8, pp. 2111-24, 2015.