Found 37 results
K. C. Entzminger, Hyun, J. -min, Pantazes, R. J., Patterson-Orazem, A. C., Qerqez, A. N., Frye, Z. P., Hughes, R. A., Ellington, A. D., Lieberman, R. L., Maranas, C. D., and Maynard, J. A., De novo design of antibody complementarity determining regions binding a FLAG tetra-peptide, Sci. Rep., vol. 7, no. 1, 2017.
A. R. Stothert, Suntharalingam, A., Tang, X., Crowley, V. M., Mishra, S. J., Webster, J. M., Nordhues, B. A., Huard, D. J. E., Passaglia, C. L., Lieberman, R. L., Blagg, B. S. J., Blair, L. J., Koren, J., and Dickey, C. A., Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma, Sci. Rep., vol. 7, no. 1, 2017.
S. E. Hill, Nguyen, E., Ukachukwu, C. U., Freeman, D. M., Quirk, S., and Lieberman, R. L., Metal ion coordination in the E. coli Nudix hydrolase dihydroneopterin triphosphate pyrophosphatase: New clues into catalytic mechanism, PLoS One, vol. 12, no. 7, 2017.
M. Kuk Joe, Lieberman, R. L., Nakaya, N., and Tomarev, S. I., Myocilin regulates metalloprotease 2 activity through interaction with TIMP3, Invest. Ophthalmol. Vis. , vol. 58, no. 12, pp. 5308-5318, 2017.
V. M. Crowley, Huard, D. J. E., Lieberman, R. L., and Blagg, B. S. J., Second Generation Grp94‐Selective Inhibitors Provide Opportunities for the Inhibition of Metastatic Cancer, Chem. Eur. J, vol. 23, no. 62, pp. 15775-15782, 2017.
S. E. Hill, Nguyen, E., Donegan, R. K., Patterson-Orazem, A. C., Hazel, A., Gumbart, J. C., and Lieberman, R. L., Structure and Misfolding of the Flexible Tripartite Coiled-Coil Domain of Glaucoma-Associated Myocilin, Structure, vol. 25, no. 11, pp. 1697-1707. e5, 2017.
S. - H. Naing, Vukoti, K. M., Drury, J. E., Johnson, J. L., Kalyoncu, S., Hill, S. E., Torres, M. P., and Lieberman, R. L., Catalytic Properties of Intramembrane Aspartyl Protease Substrate Hydrolysis Evaluated Using a FRET Peptide Cleavage Assay., ACS Chem Biol, vol. 10, no. 9, pp. 2166-74, 2015.
R. K. Donegan and Lieberman, R. L., Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions., J Med Chem, 2015.
K. C. Entzminger, Johnson, J. L., Hyun, J., Lieberman, R. L., and Maynard, J. A., Increased Fab thermoresistance via VH-targeted directed evolution., Protein Eng Des Sel, vol. 28, no. 10, pp. 365-77, 2015.
S. E. Hill, Donegan, R. K., Nguyen, E., Desai, T. M., and Lieberman, R. L., Molecular Details of Olfactomedin Domains Provide Pathway to Structure-Function Studies., PLoS One, vol. 10, no. 6, p. e0130888, 2015.
J. L. Johnson, Entzminger, K. C., Hyun, J., Kalyoncu, S., Heaner, D. P., Morales, I. A., Sheppard, A., Gumbart, J. C., Maynard, J. A., and Lieberman, R. L., Structural and biophysical characterization of an epitope-specific engineered Fab fragment and complexation with membrane proteins: implications for co-crystallization., Acta Crystallogr D Biol Crystallogr, vol. 71, no. Pt 4, pp. 896-906, 2015.
R. K. Donegan, Hill, S. E., Freeman, D. M., Nguyen, E., Orwig, S. D., Turnage, K. C., and Lieberman, R. L., Structural basis for misfolding in myocilin-associated glaucoma., Hum Mol Genet, vol. 24, no. 8, pp. 2111-24, 2015.
S. Kalyoncu, Hyun, J., Pai, J. C., Johnson, J. L., Entzminger, K., Jain, A., Heaner, D. P., Morales, I. A., Truskett, T. M., Maynard, J. A., and Lieberman, R. L., Effects of protein engineering and rational mutagenesis on crystal lattice of single chain antibody fragments, Proteins: Structure, Function, and Bioinformatics, vol. 82, no. 9, pp. 1884 - 1895, 2014.
A. R. Stothert, Suntharalingam, A., Huard, D. J. E., Fontaine, S. N., Crowley, V. M., Mishra, S., Blagg, B. S. J., Lieberman, R. L., and Dickey, C. A., Exploiting the interaction between Grp94 and aggregated myocilin to treat glaucoma., Hum Mol Genet, vol. 23, no. 24, pp. 6470-80, 2014.
S. E. Hill, Donegan, R. K., and Lieberman, R. L., The glaucoma-associated olfactomedin domain of myocilin forms polymorphic fibrils that are constrained by partial unfolding and peptide sequence., J Mol Biol, vol. 426, no. 4, pp. 921-35, 2014.
S. D. Orwig, Chi, P. V., Du, Y., Hill, S. E., Cavitt, M. A., Suntharalingam, A., Turnage, K. C., Dickey, C. A., France, S., Fu, H., and Lieberman, R. L., Ligands for glaucoma-associated myocilin discovered by a generic binding assay., ACS Chem Biol, vol. 9, no. 2, pp. 517-25, 2014.
Y. Yu, Mena-Barragán, T., Higaki, K., Johnson, J. L., Drury, J. E., Lieberman, R. L., Nakasone, N., Ninomiya, H., Tsukimura, T., Sakuraba, H., Suzuki, Y., Nanba, E., Mellet, C. Ortiz, Fernández, J. M. García, and Ohno, K., Molecular basis of 1-deoxygalactonojirimycin arylthiourea binding to human α-galactosidase a: pharmacological chaperoning efficacy on Fabry disease mutants., ACS Chem Biol, vol. 9, no. 7, pp. 1460-9, 2014.
C. M. Bethel and Lieberman, R. L., Protein Structure and Function: An Interdisciplinary Multimedia-Based Guided-Inquiry Education Module for the High School Science Classroom, Journal of Chemical Education, vol. 91, no. 1, pp. 52 - 55, 2014.